The programme aims to improve outcomes for patients suffering from single ventricle heart disease.

The Single Ventricle Research Fund (SVRF), operated by the US non-profit Additional Ventures, is an annual research award programme that supports foundational research to improve outcomes for single ventricle heart disease patients. Submissions are now open for its 2027 edition.

By addressing the organ and multi-organ level complications and clinical sequalae that drive long term morbidity and mortality, the SVRF seeks to close critical gaps in understanding and treating the disease, enabling better, more predictive and preventive care. For the 2027 cycle, the SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease. Of particular interest are proposals that seek to elucidate the mechanisms that underlie, prevent or reverse the interrelated organ- and multi-organ-level sequelae that contribute to long term morbidity and mortality.

Applications are welcome from around the world. Eligible projects must be led by a Principal Investigator (PI) holding a doctoral degree (PhD, MD, PsyD, or equivalent). All applicants must be affiliated with a non-profit academic or research institution. Certain qualified government agencies with active biomedical research programmes may also apply.

There are two programme tracks – Independent Investigator and Career Development.

Independent Investigator Track: Grants of up to $600,000 in direct costs are provided for a period of up to three years. Eligible investigators include independent investigators of all levels (including those with Instructor or Assistant Professor status). Collaborative proposals (eg including multiple lead investigators who make significant contributions’) are encouraged. One PI must be selected as the primary contact, with all other lead investigators listed as co-investigators. Up to five co-investigators may be added to each project and they must meet the same eligibility criteria as the PI.

Career Development Track: Awards of up to $300,000 in direct costs are provided for a period of up to three years. Eligible investigators include postdoctoral fellows (or equivalent) holding a mentored position who completed their terminal doctoral degree within the last 10 years. Collaborative proposals are not accepted through this track.